hla haplotype meaning in English
hla单倍型
Examples
- At present , in an attempt to stimulate specific antitumor immunity , experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes . however , there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens . 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype , the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype , the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells
但是，学者们发现这一疗法存在着如下的缺陷：单一ctl表位抗原肽的应用其抗肿瘤作用弱于多种肿瘤抗原的联合应用，且有诱导免疫耐受的潜在危险，有时反而会促进肿瘤的生长；事先需对患者的hla单倍型进行鉴定，以确定ctl表位与hla单倍型是否匹配，目前尚缺乏能与所有hla单倍型相匹配的ctl表位，从而限制了这一疗法的应用；这一疗法所产生的ctl在体外能有效杀伤经肿瘤抗原肽共孵育过的靶细胞，但对肿瘤细胞的杀伤能力较弱：这种l表位抗原肽缺乏cd4汀h细胞相关的表位，因此，不能诱导有效的th细胞免疫应答。